Hormonal and metabolic abnormalities have been reported in men with early-onset androgenetic alopecia (AGA). Although this has been ascribed to the existence of a male polycystic ovary syndrome (PCOS)-equivalent, data on this topic are inconsistent and this syndrome has not been already acknowledged. To evaluate if, already before the age of 35 years, any diference occurs in the glycolipid and hormonal profles and in the body weight in men with AGA compared to age-matched controls, we performed a comprehensive meta-analysis of all the available observational case-control studies of literature, using MEDLINE, Google Schoolar and Scopus databases. Among 10596 papers retrieved, seven studies were fnally included, enrolling a total of 1009 participants. Our fndings demonstrate that young men with AGA have a slightly but signifcantly worse glycolipid profle compared to controls and a hormonal pattern resembling those of women with PCOS, already before the age of 35 years. Therefore, early-onset AGA might represent a phenotypic sign of the male PCOS-equivalent. The acknowledgement of this syndrome would be of importance to prevent the long-term consequences on health in the afected men. The glycolipid profle and the body weight should be monitored in men with AGA starting from the second decade of life

Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A meta-analysis.

CANNARELLA, ROSSELLA
Primo
Conceptualization
;
LA VIGNERA, SANDRO SALVUCCIO MARIA
Conceptualization
;
CONDORELLI, ROSITA ANGELA
Secondo
Formal Analysis
;
CALOGERO, Aldo Eugenio
Ultimo
Writing – Review & Editing
2017

Abstract

Hormonal and metabolic abnormalities have been reported in men with early-onset androgenetic alopecia (AGA). Although this has been ascribed to the existence of a male polycystic ovary syndrome (PCOS)-equivalent, data on this topic are inconsistent and this syndrome has not been already acknowledged. To evaluate if, already before the age of 35 years, any diference occurs in the glycolipid and hormonal profles and in the body weight in men with AGA compared to age-matched controls, we performed a comprehensive meta-analysis of all the available observational case-control studies of literature, using MEDLINE, Google Schoolar and Scopus databases. Among 10596 papers retrieved, seven studies were fnally included, enrolling a total of 1009 participants. Our fndings demonstrate that young men with AGA have a slightly but signifcantly worse glycolipid profle compared to controls and a hormonal pattern resembling those of women with PCOS, already before the age of 35 years. Therefore, early-onset AGA might represent a phenotypic sign of the male PCOS-equivalent. The acknowledgement of this syndrome would be of importance to prevent the long-term consequences on health in the afected men. The glycolipid profle and the body weight should be monitored in men with AGA starting from the second decade of life
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/309919
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