This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromobenzo[b]thiophene was also studied.
Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and their 5-chloro derivatives
Guerrera, F.;Salerno, L.;Sarva, M. C.;Siracusa, M. A.;
1992-01-01
Abstract
This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromobenzo[b]thiophene was also studied.File in questo prodotto:
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