This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromobenzo[b]thiophene was also studied.
|Titolo:||Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and their 5-chloro derivatives|
|Data di pubblicazione:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|