To study the pattern of thyroglobulin (Tg) serum concentrations in the first days of life, Tg, TSH, T3and T4were measured in both maternal and cord blood at delivery and 1, 6, 12, 24, 48, 72, and 96 h after birth in 16 newborns. Tglevels at birth were higher in cord blood than in maternal blood. After birth, a prolonged Tg rise occurred. The increased levels became significant at 6 h and were maintained throughout the study. Tg levels were not correlated with serum levels of T3T4and TSH. We conclude that either a reduced Tg MCR or an increased thyroidal secretion of Tg after endogenous TSH stimulation in the newborn is a possible explanation for the elevated Tg levels occurring during the first days of life. © 1981 by The Endocrine Society.
Serum thyroglobulin levels in the newborn
Pezzino, Vincenzo;Belfiore, Antonino;Vigneri, Riccardo
1981-01-01
Abstract
To study the pattern of thyroglobulin (Tg) serum concentrations in the first days of life, Tg, TSH, T3and T4were measured in both maternal and cord blood at delivery and 1, 6, 12, 24, 48, 72, and 96 h after birth in 16 newborns. Tglevels at birth were higher in cord blood than in maternal blood. After birth, a prolonged Tg rise occurred. The increased levels became significant at 6 h and were maintained throughout the study. Tg levels were not correlated with serum levels of T3T4and TSH. We conclude that either a reduced Tg MCR or an increased thyroidal secretion of Tg after endogenous TSH stimulation in the newborn is a possible explanation for the elevated Tg levels occurring during the first days of life. © 1981 by The Endocrine Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
