Effectiveness of intranasal sodium hyaluronate in mitigating adverse effects of nasal continuous positive airway pressure therapy

Nasal continuous positive airway pressure (CPAP) in moderate to severe cases of obstructive sleep apnea can cause nasal discomfort and other undesirable problems.The aim of our study was to test the effects of sodium hyaluronate on nasal problems that patients experienced in their daily lives, sleepiness, nasal resistance to airflow, nasal mucociliary clearance, changes in inflammatory markers and compliance to CPAP in three groups of patients with obstructive sleep apnea syndrome on CPAP therapy. A total of 102 patients with a confirmed diagnosis of obstructive sleep apnea syndrome were randomized into three treatment groups: (1) hyaluronate plus CPAP, (2) saline solution plus CPAP, and (3) CPAP only-groups. Intranasal hyaluronate showed significant benefits in patients who received CPAP therapy, but future studies over a longer period of time after treatment should be performed to corroborate our findings