Objective: Temporomandibular joint dysfunction (TMD) may affect a patientâs quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD. Methods: Thirty-nine human disc samples were collected and composed three different groups: ADDwR (nÂ =Â 19), ADDwoR (nÂ =Â 12), and control group (nÂ =Â 8). The samples were immunostained with IL-1R1 antibody and evaluated on both quantity and intensity of staining. Results: There was a statistically significant difference (pÂ <Â 0.05) between the control and test groups for both quantity and intensity of staining. Conclusion: IL1-R1 was associated with ADDwR and ADDwoR in TMD discs of humans.
|Titolo:||Immunohistochemical analysis of IL-1 Receptor 1 in the discs of patients with temporomandibular joint dysfunction|
|Data di pubblicazione:||2018|
|Appare nelle tipologie:||1.1 Articolo in rivista|