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EnglishObjective: Temporomandibular joint dysfunction (TMD) may affect a patientâs quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD. Methods: Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR (n = 12), and control group (n = 8). The samples were immunostained with IL-1R1 antibody and evaluated on both quantity and intensity of staining. Results: There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining. Conclusion: IL1-R1 was associated with ADDwR and ADDwoR in TMD discs of humans.
| Titolo: | Immunohistochemical analysis of IL-1 Receptor 1 in the discs of patients with temporomandibular joint dysfunction |
| Autori interni: | |
| Data di pubblicazione: | 2018 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11769/323379 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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