Although Prostatosis (P) appears to be the most common inflammatory entity among prostatitis syndromes, its etiology, diagnosis and treatment are still controversial. The aim of this study was to examine whether an enhanced drainage in prostatic secretions obtained through chronic treatment with a muco-active proteolytic enzyme drug, was able to influence qualitative and/or quantitative expressions of bacterial growth in seminal cultures from both 199 patients with chronic prostatitis syndromes (103 with bacterial prostatitis, BP, and 96 with prostatosis, P) and 10 healthy men were followed during a 6 month period of treatment with Serratio-Peptidase (SP) and after its withdrawal. In pre-treatment, the BP group had a prevalent number (55/103) of microbial isolates at concentrations of 1 x 104 CFU/ml; during SP treatment, although the same species initially isolated were found, this group exhibited an early and progressive increase of bacterial density, reaching a prevalent number of isolates with 1 x 106 CFU/ml after 6 months in 31 specimens. Moreover, at the end of treatment, 29 out of 103 (28%) BP patients became germ negative in their seminal specimens. In P group, during SP-treatment the number of positive cultures increased from 0 to 34 out of 96 cases (35%): on months 6, positive cultures specimens showed a prevalent number (19/34) of isolates with 1 x 105 CFU/ml, while only in 5 out of 34 specimens colony counts of ≥ 1 x 106 were registered. Two months after withdrawal of SP, although among BP patients the total number of isolates and CFU counts remained unmodified vs their correlative values observed during month 6 of treatment, these microbial parameters showed significant variations among P patients: 9 out of 34 cultures became negative and the other specimens, although remaining positive for bacterial growth, exhibited a prevalent total number of isolates at 1 x 104 CFU/ml with significant difference between these distributions and those observed during month 6 of treatment. In BP patients, during SP-treatment the number of isolates for each CFU studied were always significantly higher than those of P patients: in addition, the study groups had always significantly different successions of isolates for each CFU examined. No bacterial isolate was detected among all healthy subjects. BP and P have their own characteristics, probably related to a different degree of bacterial adherence, with relative faulty elimination in these forms. Their chronic treatment with a proteolytic- enzyme mucoactive drug, probably through a decrease in bacterial adherence seems to be an important tool to well define diagnostic bacteriological criteria.
|Titolo:||Differential enhancing effect of chronic treatment with Serratio-peptidase on seminal bacterial detection from patients with chronic bacterial prostatitis/prostatosis probably related to several degree of bacterial adherence.|
|Data di pubblicazione:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|