Background Bioresorbable vascular scaffolds (BVS) have been heralded with potential benefits that are especially desired in long lesions, including chronic total occlusions (CTOs). Procedural feasibility and mid-term outcomes of BVS in CTOs have been reported. However, there is still a paucity of data regarding the vascular and healing response to BVS in CTOs evaluated by optical coherence tomography (OCT). Methods This study included prospectively 21 patients who had a CTO lesion treated with a BVS. Angiography and OCT scan were recorded at either post-implantation and 1-year follow-up. Quantitative coronary angiography and OCT analyses were performed by an independent core laboratory. Results The angiographic analysis showed a significant increase in the percentage of in-segment diameter stenosis at 1 year (11.89 Â± 9.5% vs. 21.84 Â± 11.7%; p = 0.002). The OCT analysis showed a trend (p = 0.07) towards increased mean scaffold area and significant reductions in mean lumen diameter (3.1 Â± 0.36 mm vs. 2.85 Â± 0.47 mm; p = 0.0046), mean lumen area (7.8 Â± 1.73 mm2vs. 6.76 Â± 2 mm2; p = 0.0082) and minimal lumen area (5.26 Â± 1.86 mm2vs. 3.56 Â± 1.52 mm2; p < 0.0001). Malapposition area and volume decreased from 0.26 Â± 0.17 mm2to 0.08 Â± 0.1 mm2(p = 0.0003) and from 14.17 Â± 12.92 mm3to 3.99 Â± 4.46 mm3(p = 0.0014), respectively. The rate of uncovered or malapposed struts, measured at the frame level, was 5.29 Â± 6.48% at 1 year. Conclusions In a small series of CTO patients treated with BVS implantation, OCT outcomes at 1 year displayed an overall favorable vascular response and healing profile.
|Titolo:||Vascular response and healing profile of everolimus-eluting bioresorbable vascular scaffolds for percutaneous treatment of chronic total coronary occlusions: A one-year optical coherence tomography analysis from the GHOST-CTO registry|
CAPRANZANO, PIERA [Writing – Review & Editing]
|Data di pubblicazione:||2018|
|Appare nelle tipologie:||1.1 Articolo in rivista|