We synthesized a new ratiometric fluorescent Cu2+probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.

A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells

Giuffrida, Maria Laura;Trusso Sfrazzetto, Giuseppe;Satriano, Cristina;Zimbone, Stefania;Tomaselli, Gaetano;Copani, Agata Graziella;Rizzarelli, Enrico
2018

Abstract

We synthesized a new ratiometric fluorescent Cu2+probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/325560
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