ABSTRACT Background. The aim of this study was to compare values of apparent diffusion coefficient (ADC) and diffusion (D) with renal function indexes, in a population of kidney transplant recipients who underwent magnetic resonance with diffusion-weighted imaging (DWI) of the transplanted graft. Materials and Methods. We studied 21 patients using a 1.5-Tesla magnetic resonance; DWI sequences were acquired with several b-values. Patients were divided into 3 groups by their creatinine clearance values: group A, clearance 60 mL/min; group B, clearance 30 and 60 mL/min; and group C, clearance 30 mL/min. ADCs values between groups were compared using the Mann–Whitney U test. Receiver operating characteristic (ROC) curves were created for prediction of normal renal function (group A) and renal failure (group C). Results. Comparing mean values of ADC between groups A and C, we observed a difference (P 0.0012), with higher values in group A. Regarding mean values of D, we observed a difference between groups A and C (P 0.022). In the comparison between contiguous groups, we observed no difference for ADC and D values. In the prediction of normal clearance values (group A), ROC curve showed an area under curve (AUC) of 0.861, with a sensitivity of 88.89% and specificity of 75% using a threshold ADC value 2.1 103 mm2/sec. For prediction of normal clearance values (group A), ROC curve showed an AUC of 0.787, with a sensitivity of 77.8% and specificity of 83.3% using a threshold D value 2.3 103 mm2/sec. Conclusion. Although studies with a larger number of patients are needed, DWI represents a promising tool for noninvasive assessment of renal function. An ADC 2.1 103 mm2/sec and a D 2.3 103 mm2/sec may be used as a threshold for predicting normal clearance.

Magnetic Resonance With Diffusion-Weighted Imaging in the Evaluation of Transplanted Kidneys: Preliminary Findings

PALMUCCI, STEFANO;VEROUX, Pierfrancesco;MILONE, Pietro;VEROUX, Massimiliano
2011

Abstract

ABSTRACT Background. The aim of this study was to compare values of apparent diffusion coefficient (ADC) and diffusion (D) with renal function indexes, in a population of kidney transplant recipients who underwent magnetic resonance with diffusion-weighted imaging (DWI) of the transplanted graft. Materials and Methods. We studied 21 patients using a 1.5-Tesla magnetic resonance; DWI sequences were acquired with several b-values. Patients were divided into 3 groups by their creatinine clearance values: group A, clearance 60 mL/min; group B, clearance 30 and 60 mL/min; and group C, clearance 30 mL/min. ADCs values between groups were compared using the Mann–Whitney U test. Receiver operating characteristic (ROC) curves were created for prediction of normal renal function (group A) and renal failure (group C). Results. Comparing mean values of ADC between groups A and C, we observed a difference (P 0.0012), with higher values in group A. Regarding mean values of D, we observed a difference between groups A and C (P 0.022). In the comparison between contiguous groups, we observed no difference for ADC and D values. In the prediction of normal clearance values (group A), ROC curve showed an area under curve (AUC) of 0.861, with a sensitivity of 88.89% and specificity of 75% using a threshold ADC value 2.1 103 mm2/sec. For prediction of normal clearance values (group A), ROC curve showed an AUC of 0.787, with a sensitivity of 77.8% and specificity of 83.3% using a threshold D value 2.3 103 mm2/sec. Conclusion. Although studies with a larger number of patients are needed, DWI represents a promising tool for noninvasive assessment of renal function. An ADC 2.1 103 mm2/sec and a D 2.3 103 mm2/sec may be used as a threshold for predicting normal clearance.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/32847
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