The aim of the present study was to detect simultaneously hemodynamic parietal events and intraluminal pressure of the Lower Esophageal Sphincter (LES), with particular regards to cyclic changes due to systo-diastolic cardiac activity. A probe for combined Intraluminal Manometric Plethysmography (IMP) and Intraluminal Impedence Plethysmography (IIP) was used. It was a Swan Ganz bipolar pacing catheter, modified by removing the latex balloon from the tip. The exposed side-hole (diameter smaller than 0.5 mm) was utilized as a terminal orifice for an infused manometry system. It was preliminarly essayed in bench tests. A perfusion rate of 1.75 ml/min was chosen as it did not induce significant elevations of the pressure base-line and allowed detection of pressure rise rates up to 300 mm Hg/s. The two metallic rings, originally designed for intracardiac stimulation, were used as low resistance electrodes to record impedence variations. Since very small shifts of recording electrodes induce important artifacts, the present experiments were carried out on curarized cats. In these conditions, artificial ventilation could be temporarily stopped to avoid any artifact due to respiration mechanics. The proposed method seems to be satisfactory enough for simultaneous acquisition of IIP and IMP data at LES level. Recordings of IIP allow to reveal changes in parietal blood content which could chiefly be referred to lamina propria and submucosa districts. On the other hand, IMP cyclic fluctuations would signal variations of total sphincteric tension, likely depending on hemodynamic events in all vascular beds of the wall. In our opinion, a more extensive analysis of IMP and IIP waves, as well as of reciprocal relationships between rheografic and manometric parameters, may provide very useful knowledges on sphincteric physiology.
|Titolo:||Registrazione simultanea di parametri reografici e manometrici dallo sfintere esofageo inferiore del gatto|
GIUFFRIDA, Rosario (Corresponding)
|Data di pubblicazione:||1985|
|Appare nelle tipologie:||1.1 Articolo in rivista|