Aims: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR). Methods: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25–29.9 kg/m2and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease. Patients were stratified in high WHR (H-WHR) or low WHR (L-WHR) group according to WHR (≥ 0.85 for women and ≥ 0.90 for men) and underwent multi-detector computed tomography for CACs. Mean carotid intima-media thickness (IMT) and plaque presence were equally assessed. Results: CACs was higher in the H-WHR group compared to L-WHR (9.05 [0.0–83.48] vs 0.0 [0.0–64.7] AU, p < 0.01); the prevalence of CACs > 0 in the H-WHR group was significantly higher than subjects with L-WHR (59.6% vs 38.5%, p < 0.001). Moreover, H-WHR group had higher mean IMT (0.64 [0.56–0.72] vs 0.59 [0.55–0.67] mm, p < 0.05) and higher carotid plaque prevalence (63.7% vs 50.8%, p < 0.05) compared to subjects with L-WHR. Logistic regression showed that H-WHR was associated with presence of CACs and carotid plaque (p < 0.01). In a multiple linear regression, WHR was positively associated with CACs and IMT (p < 0.01). Conclusions: H-WHR is a marker of coronary and peripheral atherosclerotic burden in overweight patients.

An increased waist-to-hip ratio is a key determinant of atherosclerotic burden in overweight subjects

Scicali, Roberto
Conceptualization
;
Di Pino, Antonino
Investigation
;
Piro, Salvatore
Investigation
;
Rabuazzo, Agata Maria
Investigation
;
Purrello, Francesco
Writing – Review & Editing
;
2018-01-01

Abstract

Aims: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR). Methods: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25–29.9 kg/m2and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease. Patients were stratified in high WHR (H-WHR) or low WHR (L-WHR) group according to WHR (≥ 0.85 for women and ≥ 0.90 for men) and underwent multi-detector computed tomography for CACs. Mean carotid intima-media thickness (IMT) and plaque presence were equally assessed. Results: CACs was higher in the H-WHR group compared to L-WHR (9.05 [0.0–83.48] vs 0.0 [0.0–64.7] AU, p < 0.01); the prevalence of CACs > 0 in the H-WHR group was significantly higher than subjects with L-WHR (59.6% vs 38.5%, p < 0.001). Moreover, H-WHR group had higher mean IMT (0.64 [0.56–0.72] vs 0.59 [0.55–0.67] mm, p < 0.05) and higher carotid plaque prevalence (63.7% vs 50.8%, p < 0.05) compared to subjects with L-WHR. Logistic regression showed that H-WHR was associated with presence of CACs and carotid plaque (p < 0.01). In a multiple linear regression, WHR was positively associated with CACs and IMT (p < 0.01). Conclusions: H-WHR is a marker of coronary and peripheral atherosclerotic burden in overweight patients.
2018
Cardiovascular risk assessment; Coronary artery calcium score; Intima-media thickness; Overweight; WHR; Internal Medicine; Endocrinology, Diabetes and Metabolism; Endocrinology
File in questo prodotto:
File Dimensione Formato  
An increased waist‐to‐hip ratio is a key determinant of atherosclerotic burden in overweight subjects.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Dimensione 1.54 MB
Formato Adobe PDF
1.54 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/329063
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 27
social impact