Multivalent calixarene-based C-fucosyl derivative: A new Pseudomonas aeruginosa biofilm inhibitor

Consoli, Grazia M. L.; Granata, Giuseppe; Cafiso, Viviana; Stefani, Stefania; Geraci, Corrada

doi:10.1016/j.tetlet.2011.08.142

The first example of multivalent conjugate in which four α-L-C-fucosyl units are clustered by means of a calix[4]arene platform was designed as a new potential Pseudomonas aeruginosa biofilm inhibitor. The anti-biofilm activity of the synthesized compound (6) against PAO1 strain was assayed and it was found to be dose-dependent. The presence of the fucose cluster improves the biofilm inhibitor efficiency as proven by the lower inhibitor activity of the analogous glycyl-calix[4]arene derivative (3) lacking in the fucose moieties. © 2011 Elsevier Ltd. All rights reserved.

Titolo:	Multivalent calixarene-based C-fucosyl derivative: A new Pseudomonas aeruginosa biofilm inhibitor
Autori interni:	Consoli, Grazia M. L. Granata, Giuseppe CAFISO, VIVIANA STEFANI, Stefania Geraci, Corrada mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2011
Rivista:	TETRAHEDRON LETTERS
Handle:	http://hdl.handle.net/20.500.11769/335178
Appare nelle tipologie:	1.1 Articolo in rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/20.500.11769/335178

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CINECA IRIS Institutional Research Information System

File in questo prodotto: