The first example of multivalent conjugate in which four α-L-C-fucosyl units are clustered by means of a calix[4]arene platform was designed as a new potential Pseudomonas aeruginosa biofilm inhibitor. The anti-biofilm activity of the synthesized compound (6) against PAO1 strain was assayed and it was found to be dose-dependent. The presence of the fucose cluster improves the biofilm inhibitor efficiency as proven by the lower inhibitor activity of the analogous glycyl-calix[4]arene derivative (3) lacking in the fucose moieties. © 2011 Elsevier Ltd. All rights reserved.
Titolo: | Multivalent calixarene-based C-fucosyl derivative: A new Pseudomonas aeruginosa biofilm inhibitor |
Autori interni: | |
Data di pubblicazione: | 2011 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11769/335178 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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