The first example of multivalent conjugate in which four α-L-C-fucosyl units are clustered by means of a calixarene platform was designed as a new potential Pseudomonas aeruginosa biofilm inhibitor. The anti-biofilm activity of the synthesized compound (6) against PAO1 strain was assayed and it was found to be dose-dependent. The presence of the fucose cluster improves the biofilm inhibitor efficiency as proven by the lower inhibitor activity of the analogous glycyl-calixarene derivative (3) lacking in the fucose moieties. © 2011 Elsevier Ltd. All rights reserved.
|Titolo:||Multivalent calixarene-based C-fucosyl derivative: A new Pseudomonas aeruginosa biofilm inhibitor|
|Data di pubblicazione:||2011|
|Appare nelle tipologie:||1.1 Articolo in rivista|