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EnglishXanthomonas maltophilia produces two inducible β-lactamases, L-1 and L-2, and resists the antimicrobial activity of β-lactam antibiotics including carbapenems. L-1 has carbapenemase activity and L-2 is a cephalosporinase. It has been suggested that these β-lactamases share regulatory components. We isolated a recent clinical X. maltophilia strain susceptible to carbapenems and resistant to almost all the other β-lactam antibiotics tested. β-Lactamase induction with cefotaxime showed that the clinical isolate had low-level expression of L-1 β-lactamase but remained inducible for L-2 enzyme. The possible relationship of this enzyme to carbapenem sensitivity is considered.
| Titolo: | Clinical isolate of a Xanthomonas maltophilia strain producing L-1-deficient and L-2-inducible β-lactamases | |
| Autori interni: | ||
| Data di pubblicazione: | 1995 | |
| Rivista: | ||
| Handle: | http://hdl.handle.net/20.500.11769/335185 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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