Two (CA) microsatellite polymorphisms have been studied in 209 subjects from Northern Italy, members of 27 Polycystic Kidney Disease families. Polymorphic alleles were analyzed by using a labelled PCR. Results obtained show that these markers highly improve the presymptomatic diagnosis of the disease in subjects at risk. In addition, our findings suggest that a region with a high recombination frequency should exist between PKD1 and SM7.
Titolo: | Analysis of polycystic kidney disease with two new microsatellite markers |
Autori interni: | |
Data di pubblicazione: | 1994 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11769/335187 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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