Two (CA) microsatellite polymorphisms have been studied in 209 subjects from Northern Italy, members of 27 Polycystic Kidney Disease families. Polymorphic alleles were analyzed by using a labelled PCR. Results obtained show that these markers highly improve the presymptomatic diagnosis of the disease in subjects at risk. In addition, our findings suggest that a region with a high recombination frequency should exist between PKD1 and SM7.
|Titolo:||Analysis of polycystic kidney disease with two new microsatellite markers|
|Data di pubblicazione:||1994|
|Appare nelle tipologie:||1.1 Articolo in rivista|