Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health. Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate. In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response. Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.

Complement system and age-related macular degeneration: Implications of gene-environment interaction for preventive and personalized medicine

Maugeri, Andrea;Barchitta, Martina;Giuliano, Francesco;Agodi, Antonella
2018-01-01

Abstract

Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health. Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate. In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response. Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.
2018
Biochemistry, Genetics and Molecular Biology (all); Immunology and Microbiology (all)
File in questo prodotto:
File Dimensione Formato  
BMRI2018-7532507.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Dimensione 1.4 MB
Formato Adobe PDF
1.4 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/335502
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 27
social impact