A case of multiple autoimmunity complicated by SIADH

Central nervous system (CNS) vasculitides are rare, often severe diseases, difficult to diagnose for the lack of specific symptoms and with a poor outcome. We report a case of CNS vasculitis in a 57-year-old patient suffering from multiorgan dysimmune syndrome characterised by celiac disease, ulcerative colitis and diabetes mellitus. Cognitive deterioration, gait impairment and balance loss were the main clinical findings, and the patient was able to walk in 3 years. Moreover, inappropriate secretion of adiuretin syndrome occurred, making the patient's treatment more complex. Methylprednisolone and monthly intravenous pulse of cyclophosphamide boosters were administered; plasma-exchange, intravenous immunoglobulins and rituximab were sequentially used with no benefit