The aim of the study was to evaluate individual inflammatory response after inguinal hernioplasty by measuring baseline and post-operative serum IL-6 response to surgery and quantifying the variability of the serum response in a homogeneous group of patients.Patients enrolled in the study underwent inguinal hernioplasty. Blood samples were used to analyze serum IL-6, TNF-alpha, LOOH and GSH levels. To identify high and low IL-6 responders, patients were divided into 2 groups according median values of the peak levels of IL-6. Mean levels of the cytokine were comparable at baseline but reached peak at 6 h and persisted elevated at following hours among high responders whereas remained significantly lower over time among low responders. Patients identified as low responders showed not significant changes in serum IL-6 levels over the postoperative period. In contrast, high responders demonstrated a significant response reaching the peak level of IL-6 after 6 hours post operation.

Low and high responders after polypropylene mesh implantation for inguinal hernioplasty

Godos, Justyna;Li Volti, Giovanni;La Camera, Giuseppa;Basile, Francesco;Biondi, Antonio;Brancato, Giovanna;Donati, Marcello
2017

Abstract

The aim of the study was to evaluate individual inflammatory response after inguinal hernioplasty by measuring baseline and post-operative serum IL-6 response to surgery and quantifying the variability of the serum response in a homogeneous group of patients.Patients enrolled in the study underwent inguinal hernioplasty. Blood samples were used to analyze serum IL-6, TNF-alpha, LOOH and GSH levels. To identify high and low IL-6 responders, patients were divided into 2 groups according median values of the peak levels of IL-6. Mean levels of the cytokine were comparable at baseline but reached peak at 6 h and persisted elevated at following hours among high responders whereas remained significantly lower over time among low responders. Patients identified as low responders showed not significant changes in serum IL-6 levels over the postoperative period. In contrast, high responders demonstrated a significant response reaching the peak level of IL-6 after 6 hours post operation.
Hernioplasty; IL-6; Inflammatory response; Polypropylene mesh; Medicine (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/336220
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