Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unlikely. The aim of this randomized cross-over study was to measure the exposure levels of the combustion marker, carbon monoxide in the exhaled breath (eCO) of subjects after use of two HTPs and to compare these levels with participants' own brand of cigarettes. A total of 12 healthy smokers who reported smoking ≥10 conventional cigarettes per day for at least 5years took part in the study. Product administration consisted of a first round of 10 puffs, which was followed by an identical second round after a 5min pause in between rounds. After obtaining a baseline eCO value, this measure was recorded at 5, 10, 15, 30, and 45min after the first puff of the first round. In contrast to combustible cigarettes, no eCO elevations were observed in the exhaled breath after use of the HTPs under investigation in any of the study participants.

Carbon monoxide levels after inhalation from new generation heated tobacco products

Caponnetto, Pasquale;Maglia, Marilena;Polosa, Riccardo
2018-01-01

Abstract

Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unlikely. The aim of this randomized cross-over study was to measure the exposure levels of the combustion marker, carbon monoxide in the exhaled breath (eCO) of subjects after use of two HTPs and to compare these levels with participants' own brand of cigarettes. A total of 12 healthy smokers who reported smoking ≥10 conventional cigarettes per day for at least 5years took part in the study. Product administration consisted of a first round of 10 puffs, which was followed by an identical second round after a 5min pause in between rounds. After obtaining a baseline eCO value, this measure was recorded at 5, 10, 15, 30, and 45min after the first puff of the first round. In contrast to combustible cigarettes, no eCO elevations were observed in the exhaled breath after use of the HTPs under investigation in any of the study participants.
2018
Combustion; Exhaled breath carbon monoxide; Heated tobacco products; Tobacco-heating products; Pulmonary and Respiratory Medicine
File in questo prodotto:
File Dimensione Formato  
Carbon monoxide levels after inhalation from new generation heated tobacco products.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Dimensione 393.57 kB
Formato Adobe PDF
393.57 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/336772
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 25
social impact