A series of 1-alkyl-3-dialkylaminoalkylamino[1]benzothieno[2,3-b]pyrazin-2(1H)-ones 5-35 was synthesized. Some of these compounds showed appreciable inhibition towards KCl-induced contractions in isolated rat aortic rings. The results obtained showed that, although this activity appears at higher concentrations than with caroverine, used as reference standard, this new tricyclic system could be considered as a nucleus with potential calcium antagonistic activity.
Synthesis of 1-alkyl-3-dialkylaminoalkylamine[1]benzothieno[2,3-b]pyrazin-2(1H)-ones and their ability to antagonize KCl-induced contractions
SALERNO, Loredana;SIRACUSA, Maria Angela;RESCIFINA, Antonio;
1996-01-01
Abstract
A series of 1-alkyl-3-dialkylaminoalkylamino[1]benzothieno[2,3-b]pyrazin-2(1H)-ones 5-35 was synthesized. Some of these compounds showed appreciable inhibition towards KCl-induced contractions in isolated rat aortic rings. The results obtained showed that, although this activity appears at higher concentrations than with caroverine, used as reference standard, this new tricyclic system could be considered as a nucleus with potential calcium antagonistic activity.File in questo prodotto:
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