A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.
SYNTHESIS OF SUBSTITUTED [1]BENZOTHIENO[2,3-B]PYRAZINES AND THEIR ABILITY TO ANTAGONIZE KCL INDUCED CONTRACTIONS
SALERNO, Loredana;SIRACUSA, Maria Angela;RESCIFINA, Antonio;
1994-01-01
Abstract
A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.File in questo prodotto:
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