An enhanced prostaglandin-like activity is shown in homogenates of brain from rats treated intracerebroventricularly with 100 μg of met-enkephalin. The increase is significantly reduced by naloxone pretreatment. A relationship is proposed between generation of prostaglandins in the brain following met-enkephalin administration and hyperthermic effect of the opiate-like factor in the rat. Normalization of prostaglandin-like activity following chronic administration of met-enkephalin in the rat may also account for the development of tolerance to its thermic effect.
Prostaglandins in the rats given, acutely and chronically, a hyperthermic dose of met-enkephalin
SCOTO, Giovanna Maria;
1979-01-01
Abstract
An enhanced prostaglandin-like activity is shown in homogenates of brain from rats treated intracerebroventricularly with 100 μg of met-enkephalin. The increase is significantly reduced by naloxone pretreatment. A relationship is proposed between generation of prostaglandins in the brain following met-enkephalin administration and hyperthermic effect of the opiate-like factor in the rat. Normalization of prostaglandin-like activity following chronic administration of met-enkephalin in the rat may also account for the development of tolerance to its thermic effect.File in questo prodotto:
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