Transforming growth factor beta 1 and vascular endothelial growth factor levels in the pathogenesis of periodontal disease

Matarese, G.; Isola, G.; Anastasi, G. P.; Cutroneo, G.; Cordasco, G.; Favaloro, A.; Vita, G.; Vermiglio, G.; Milardi, D.; Zizzari, V. L.; Tetè, S.; Perillo, L.

doi:10.1177/1721727X1301100217

Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology of periodontal disease. Cytokines play crucial roles in the maintenance of tissue homeostasis, a process which requires a delicate balance between anabolic and catabolic activities. In particular, two families of growth factors-such as transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) are thought to play important roles in modulating the proliferation and/or migration of structural cells involved in inflammation and regulation of immune responses. The aim of this work was to analyze gingival samples and periodontal tissue specimens collected from thirty-eight patients with chronic periodontal disease and from forty healthy individuals, in order to detect the expression and distribution of TGF-β1 and VEGF between the two groups. TGF-β1 and VEGF expression levels were detected using immunohistochemical analysis and computer-assisted morphometric analysis. The findings presented here suggest that biomarker such as TGF-β1 and VEGF have an important regulating role in the orchestration of the immune response, which in turn influence the outcome of disease establishment and evolution. Copyright © by BIOLIFE, s.a.s.

Titolo:	Transforming growth factor beta 1 and vascular endothelial growth factor levels in the pathogenesis of periodontal disease
Autori interni:	G. Matarese ISOLA, GAETANO (Co-primo) (Corresponding) G. P. Anastasi G. Cutroneo G. Cordasco A. Favaloro G. Vita G. Vermiglio D. Milardi V. L. Zizzari S. Tetè L. Perillo mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2013
Rivista:	EUROPEAN JOURNAL OF INFLAMMATION
Handle:	http://hdl.handle.net/20.500.11769/345190
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/345190

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