Objective: The role of the dose and route of administration of octreotide in addition to insulin on daily blood glucose: growth hormone, glucagon, cortisol and adrenaline profiles in 7 insulin-dependent diabetic patients have been studied. Octreotide was administered either as multiple subcutaneous injections (50 mu g three times daily, total dose 150 mu g) or by continuous subcutaneous infusion of lower 62.5 mu g 24/h and 112.5 mu g 24/h. Results: Blood glucose and growth hormone concentrations were lowered by octreotide in a similar manner regardless of the route of administration and dose. Glucagon concentrations at 12 and 16 h were reduced by all octreotide doses, but fasting at 20, 24 and 04 h concentrations were lowered only by 113 mu g given by continuous infusion. Cortisol and adrenaline concentrations were not modified. Conclusions: Thus, low doses of octreotide administered by continuous infusion in addition to standard insulin treatment displayed the same hypoglycaemic effect as larger doses given by multiple injections without causing adverse-effects or hypoglycaemic episodes.
Effect of octreotide on blood glucose and counterregulatory hormones in insulin-dependent diabetic patients: The role of dose and route of administration
DI MAURO, Maurizio;NICOLETTI, FERDINANDO
1996-01-01
Abstract
Objective: The role of the dose and route of administration of octreotide in addition to insulin on daily blood glucose: growth hormone, glucagon, cortisol and adrenaline profiles in 7 insulin-dependent diabetic patients have been studied. Octreotide was administered either as multiple subcutaneous injections (50 mu g three times daily, total dose 150 mu g) or by continuous subcutaneous infusion of lower 62.5 mu g 24/h and 112.5 mu g 24/h. Results: Blood glucose and growth hormone concentrations were lowered by octreotide in a similar manner regardless of the route of administration and dose. Glucagon concentrations at 12 and 16 h were reduced by all octreotide doses, but fasting at 20, 24 and 04 h concentrations were lowered only by 113 mu g given by continuous infusion. Cortisol and adrenaline concentrations were not modified. Conclusions: Thus, low doses of octreotide administered by continuous infusion in addition to standard insulin treatment displayed the same hypoglycaemic effect as larger doses given by multiple injections without causing adverse-effects or hypoglycaemic episodes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.