Host-guest interactions studied in supramolecular chemistry have been inspired by interactions between enzymes and substrates. Furthermore, most of the interactions involved in the cells are based on non-covalent bonds between two or more molecules. The common aspects between supramolecular chemistry and medicine have led to the development of a “new” area called “supramolecular medicine”, in which non-covalent interactions and self-assembly processes are applied within several medical fields. The object of this Digest is to offer an account of how some macrocyclic hosts (e.g. cucurbiturils, cyclodextrins, pillararenes and calixarenes) are employed in supramolecular medicine creating new supramolecular hydrogels used as biomaterials for human tissue in regenerative medicine, and a diagnostic instrument, in-vitro and in-vivo, for the detection of diseases, as well as for the investigation of cell morphology.

Supramolecular complexes for nanomedicine

Puglisi, Roberta;Pappalardo, Andrea;Trusso Sfrazzetto, Giuseppe
2018-01-01

Abstract

Host-guest interactions studied in supramolecular chemistry have been inspired by interactions between enzymes and substrates. Furthermore, most of the interactions involved in the cells are based on non-covalent bonds between two or more molecules. The common aspects between supramolecular chemistry and medicine have led to the development of a “new” area called “supramolecular medicine”, in which non-covalent interactions and self-assembly processes are applied within several medical fields. The object of this Digest is to offer an account of how some macrocyclic hosts (e.g. cucurbiturils, cyclodextrins, pillararenes and calixarenes) are employed in supramolecular medicine creating new supramolecular hydrogels used as biomaterials for human tissue in regenerative medicine, and a diagnostic instrument, in-vitro and in-vivo, for the detection of diseases, as well as for the investigation of cell morphology.
2018
Bioimaging; Biomaterials; Nanomedicine; Self-repairing; Supramolecular chemistry; Biochemistry; Molecular Medicine; Molecular Biology; 3003; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/357747
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