Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
|Titolo:||The active role of Ca2+ions in Aβ-mediated membrane damage|
LA ROSA, Carmelo [Membro del Collaboration Group] (Corresponding)
|Data di pubblicazione:||2018|
|Appare nelle tipologie:||1.1 Articolo in rivista|