Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.

The active role of Ca2+ions in Aβ-mediated membrane damage

La Rosa, Carmelo
Membro del Collaboration Group
;
2018-01-01

Abstract

Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
2018
Amyloid; Amyloid beta-Peptides; Animals; Calcium; Cell Membrane; Fluoresceins; Fluorescent Dyes; Fura-2; Kinetics; Mice; Peptide Fragments; Porosity; Protein Multimerization; Catalysis; Electronic, Optical and Magnetic Materials; Ceramics and Composites; Chemistry (all); Surfaces, Coatings and Films; 2506; Materials Chemistry2506 Metals and Alloys
File in questo prodotto:
File Dimensione Formato  
CC_54_3629_2018.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.79 MB
Formato Adobe PDF
1.79 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/357831
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 24
social impact