The synthesis of orthogonally protected 3-(aminomethyl)-2-(carboxymethyl)isoxazolidinyl thymine, a convenient monomer for the preparation of novel isoxazolidinyl peptide nucleic acid analogues, has been achieved through enantioselective 1,3-dipolar cycloaddition between N-glycosyl nitrones and vinyl acetate.
3-(Aminomethyl)-2-(carboxymethyl)isoxazolidinyl nucleosides: building blocks for peptide nucleic acid analogues
CHIACCHIO, Ugo;CORSARO, Antonino;
2007-01-01
Abstract
The synthesis of orthogonally protected 3-(aminomethyl)-2-(carboxymethyl)isoxazolidinyl thymine, a convenient monomer for the preparation of novel isoxazolidinyl peptide nucleic acid analogues, has been achieved through enantioselective 1,3-dipolar cycloaddition between N-glycosyl nitrones and vinyl acetate.File in questo prodotto:
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