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EnglishVal600Glu (V600E) mutation is the most common BRAF mutation detected in thyroid cancer. Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. Among them, vemurafenib is a selective BRAF inhibitor approved by FDA for clinical practice. Unfortunately, vemurafenib often displays limited efficacy in poorly differentiated and anaplastic thyroid carcinomas probably because of intrinsic and/or acquired resistance mechanisms. In this view, cancer stem cells may represent a possible mechanism of resistance to vemurafenib, due to their self-renewal and chemo resistance properties.
| Titolo: | Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells |
| Autori interni: | |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Abstract: | Val600Glu (V600E) mutation is the most common BRAF mutation detected in thyroid cancer. Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. Among them, vemurafenib is a selective BRAF inhibitor approved by FDA for clinical practice. Unfortunately, vemurafenib often displays limited efficacy in poorly differentiated and anaplastic thyroid carcinomas probably because of intrinsic and/or acquired resistance mechanisms. In this view, cancer stem cells may represent a possible mechanism of resistance to vemurafenib, due to their self-renewal and chemo resistance properties. |
| Handle: | http://hdl.handle.net/20.500.11769/358345 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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| Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells.pdf | Versione Editoriale (PDF) | Administrator |
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