The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study

Pagano, Duilio; Oliva, Elisabetta; Khouzam, Simone; Tuzzolino, Fabio; Cintorino, Davide; Li Petri, Sergio; di Francesco, Fabrizio; Ricotta, Calogero; Bonsignore, Pasquale; Tropea, Alessandro; Calamia, Sergio; Costanzo, Federico; Luca, Angelo; Gruttadauria, Salvatore

doi:10.1186/s12893-018-0455-7

Liver transplantation is the best treatment for end-stage liver disease. The interruption of the blood supply to the donor liver during cold storage damages the liver, affecting how well the liver will function after transplant. The drug Simvastatin may help to protect donor livers against this damage and improve outcomes for transplant recipients. The aim of this study is to evaluate the benefits of treating the donor liver with Simvastatin compared with the standard transplant procedure.

Titolo:	The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study
Autori interni:	Pagano, Duilio Oliva, Elisabetta Khouzam, Simone Tuzzolino, Fabio Cintorino, Davide Li Petri, Sergio di Francesco, Fabrizio Ricotta, Calogero Bonsignore, Pasquale TROPEA, ALESSANDRO Calamia, Sergio Costanzo, Federico DE LUCA, Angelo GRUTTADAURIA, Salvatore Giovanni mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Rivista:	BMC SURGERY
Abstract:	Liver transplantation is the best treatment for end-stage liver disease. The interruption of the blood supply to the donor liver during cold storage damages the liver, affecting how well the liver will function after transplant. The drug Simvastatin may help to protect donor livers against this damage and improve outcomes for transplant recipients. The aim of this study is to evaluate the benefits of treating the donor liver with Simvastatin compared with the standard transplant procedure.
Handle:	http://hdl.handle.net/20.500.11769/358660
Appare nelle tipologie:	1.1 Articolo in rivista

File in questo prodotto:

File	Descrizione	Tipologia	Licenza
Pagano_et_al-2018-BMC_Surgery.pdf		Versione Editoriale (PDF)		Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/20.500.11769/358660

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CINECA IRIS Institutional Research Information System

File in questo prodotto: