Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis. © 2003 Elsevier Ltd. All rights reserved.

Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients

Palumbo, Giuseppe Alberto;
2004

Abstract

Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis. © 2003 Elsevier Ltd. All rights reserved.
AML; BCRP; MDR1; Multidrug resistance; Quantitative PCR; Real-time PCR; Hematology; Oncology; Cancer Research
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/358768
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