We analyzed FcγRIIIA-158V/F and FcγRIIA-131H/R polymorphisms in a cohort of 94 newly diagnosed follicular lymphoma (FL) patients sequentially treated with CHOP and Rituximab. With a median follow-up of 5.8 years, the overall survival at 8 years is 83%. Univariate and multivariate analysis showed no correlation between FcγRIIIA-158VV/VF and FcγRIIA-131HH/HR polymorphisms and the overall response rate, the molecular response and the event-free survival obtained after CHOP and Rituximab. By contrast, the achievement of a durable molecular clearance of BCL2/IgH+cells detectable in the bone marrow is confirmed to be a reliable predictive factor of a better long-term clinical outcome. ©2007 Ferrata Storti Foundation.

FcγRIIIA and FcγRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab

Palumbo, Giuseppe A.;Tibullo, Daniele;
2007

Abstract

We analyzed FcγRIIIA-158V/F and FcγRIIA-131H/R polymorphisms in a cohort of 94 newly diagnosed follicular lymphoma (FL) patients sequentially treated with CHOP and Rituximab. With a median follow-up of 5.8 years, the overall survival at 8 years is 83%. Univariate and multivariate analysis showed no correlation between FcγRIIIA-158VV/VF and FcγRIIA-131HH/HR polymorphisms and the overall response rate, the molecular response and the event-free survival obtained after CHOP and Rituximab. By contrast, the achievement of a durable molecular clearance of BCL2/IgH+cells detectable in the bone marrow is confirmed to be a reliable predictive factor of a better long-term clinical outcome. ©2007 Ferrata Storti Foundation.
BCL2/IgH rearrangements; FcγR polymorphisms; Follicular lymphoma; Hematology
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/358775
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