ACTIVITY OF OFLOXACIN AND SPIRAMYCIN IN ORAL SURGERY

Forty patients undergoing surgeryfor infections of the oral cavitywere randomly allocated to oral treatment with ofloxacin (Oflocin) 300mg (20 patients) or spiramycin 3,000,00 iu (20 patients) twice daily for a period starting just before surgery and lasting unitil three days after surgery. Bacteriological cultures were drawn before and after treatment. Antibiotic susceptibilities were determined by the Kirby-Bauer agar diffusion disc method, 95% of ofloxacin-treated patients proving sensitive to treatment as against 75% of patients in the spiramycin group. Clinical results, based on incidence of post-surgical infection, showed 95% success for ofloxacin and 80% spiramycin.The results indicated that both drugs are effective in the prophylaxis of oral post-surgical infections, microbiological and clinical findings being significantly better for ofloxacin.