MICROBIOLOGICAL BASIC FOR THE USE OF FOSFOMYCIN TROMETAMOL AS SINGLE-DOSE THERAPY FOR SIMPLE CISTITIS.

Fosfomycin trometamol (FOT), a new soluble salt of fosfomycin, was developed especially for single-dose treatment in uncomlicated urinary tract infections. In this study, the minimum inhibitory concentrations (MICs) of FOT were measured both in nutrient broth and human urine and compared with calcium fosfomycin, pipemidic acid and cotrimoxazole. A total of 300 bacterial strains of dfferent species from recent urinary infections were studied. No differences were observed between the two fosfomycin salts. The fosfomycin concentrations of 137-1550ug/ml, easily obtained in urine of healthy adult subjects after a single dose of FOT (3g of fosfomycin), were able to kill all the strains, with the exeception of Streptococcus faecalis. The bacerial adhesion of a resistant microrganism (P.aeruginosa) to the cells of the urinary tract, showed a 50% reduction after FOT treatment.