We have performed FISH analysis, using the Locus Specific Identifier FOX1 Break Apart Probe (Vysis-Abbot) which hibridizes to band 13q14, to better classify the oral cavity tumor. Notably, monoallelic loss of the FOX1/13q14 locus was detected in 50% of cell population. Based on this novel finding we think that the tumor originally labeled as “polypoid angiomyofibroblastoma-like tumour of oral cavity” could be better re-classified as small round cell variant of myofibroblastoma.

Small round cell myofibroblastoma of the oral cavity: A tumor mimicking embryonal rhabdomyosarcoma

Magro, Gaetano
Primo
Conceptualization
;
Angelico, Giuseppe;Salvatorelli, Lucia
Ultimo
2018

Abstract

We have performed FISH analysis, using the Locus Specific Identifier FOX1 Break Apart Probe (Vysis-Abbot) which hibridizes to band 13q14, to better classify the oral cavity tumor. Notably, monoallelic loss of the FOX1/13q14 locus was detected in 50% of cell population. Based on this novel finding we think that the tumor originally labeled as “polypoid angiomyofibroblastoma-like tumour of oral cavity” could be better re-classified as small round cell variant of myofibroblastoma.
Adolescent; Female; Humans; Mouth; Neoplasm Metastasis; Neoplasms, Muscle Tissue; Rhabdomyosarcoma, Embryonal; Diagnosis, Differential; 2734; Cell Biology
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/360679
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 2
social impact