Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-beta 1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-beta 1 translocation has been evaluated by in vitro assays.
|Titolo:||Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||1.1 Articolo in rivista|