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EnglishUnderstanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-beta 1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-beta 1 translocation has been evaluated by in vitro assays.
| Titolo: | Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol |
| Autori interni: | |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11769/361411 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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