Objective: To test the association between coffee consumption and risk of all-cause, CVD and cancer death in a European cohort. Design: Prospective cohort study. Cox proportional hazards models with adjustment for potential confounders to estimate multivariable hazard ratios (HR) and 95 % CI were used. Setting: Czech Republic, Russia and Poland. Subjects: A total of 28561 individuals followed for 6·1 years. Results: A total of 2121 deaths (43·1 % CVD and 35·7 % cancer mortality) occurred during the follow-up. Consumption of 3-4 cups coffee/d was associated with lower mortality risk in men (HR=0·83; 95 % CI 0·71, 0·99) and women (HR=0·63; 95 % CI 0·47, 0·84), while further intake showed non-significant reduced risk estimates (HR=0·71; 95 % CI 0·49, 1·04 and HR=0·51; 95 % CI 0·24, 1·10 in men and women, respectively). Decreased risk of CVD mortality was also found in men (HR=0·71; 95 % CI 0·54, 0·93) for consumption of 3-4 cups coffee/d. Stratified analysis revealed that consumption of a similar amount of coffee was associated with decreased risk of all-cause (HR=0·61; 95 % CI 0·43, 0·87) and cancer mortality (HR=0·59; 95 % CI 0·35, 0·99) in non-smoking women and decreased risk of all-cause mortality for >4 cups coffee/d in men with no/moderate alcohol intake. Conclusions: Coffee consumption was associated with decreased risk of mortality. The protective effect was even stronger when stratification by smoking status and alcohol intake was performed.

Coffee consumption and mortality in three Eastern European countries: Results from the HAPIEE (Health, Alcohol and Psychosocial factors in Eastern Europe) study

Grosso, Giuseppe
;
2017

Abstract

Objective: To test the association between coffee consumption and risk of all-cause, CVD and cancer death in a European cohort. Design: Prospective cohort study. Cox proportional hazards models with adjustment for potential confounders to estimate multivariable hazard ratios (HR) and 95 % CI were used. Setting: Czech Republic, Russia and Poland. Subjects: A total of 28561 individuals followed for 6·1 years. Results: A total of 2121 deaths (43·1 % CVD and 35·7 % cancer mortality) occurred during the follow-up. Consumption of 3-4 cups coffee/d was associated with lower mortality risk in men (HR=0·83; 95 % CI 0·71, 0·99) and women (HR=0·63; 95 % CI 0·47, 0·84), while further intake showed non-significant reduced risk estimates (HR=0·71; 95 % CI 0·49, 1·04 and HR=0·51; 95 % CI 0·24, 1·10 in men and women, respectively). Decreased risk of CVD mortality was also found in men (HR=0·71; 95 % CI 0·54, 0·93) for consumption of 3-4 cups coffee/d. Stratified analysis revealed that consumption of a similar amount of coffee was associated with decreased risk of all-cause (HR=0·61; 95 % CI 0·43, 0·87) and cancer mortality (HR=0·59; 95 % CI 0·35, 0·99) in non-smoking women and decreased risk of all-cause mortality for >4 cups coffee/d in men with no/moderate alcohol intake. Conclusions: Coffee consumption was associated with decreased risk of mortality. The protective effect was even stronger when stratification by smoking status and alcohol intake was performed.
Coffee; Cohort; Europe; Mortality; Prospective; Aged; Alcohol Drinking; Cardiovascular Diseases; Czech Republic; Female; Follow-Up Studies; Humans; Life Style; Male; Middle Aged; Neoplasms; Nutrition Assessment; Poland; Proportional Hazards Models; Prospective Studies; Risk Factors; Russia; Surveys and Questionnaires; Coffee; Medicine (miscellaneous); Nutrition and Dietetics; Public Health, Environmental and Occupational Health
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/361442
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