Positive Caricature Transcriptomic Effects Associated with Broad Genomic Aberrations in Colorectal Cancer

Condorelli, Daniele F.; Spampinato, Giorgia; Valenti, Giovanna; Musso, Nicolò; Castorina, Sergio; Barresi, Vincenza

doi:10.1038/s41598-018-32884-3

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We re-examined the correlation between Broad Genomic Aberrations (BGAs) and transcriptomic profiles in Colorectal Cancer (CRC). Two types of BGAs have been examined: Broad Copy-Number Abnormal regions (BCNAs), distinguished in gain- and loss-type, and Copy-Neutral Loss of Heterozygosities (CNLOHs). Transcripts are classified as “OverT” or “UnderT” if overexpressed or underexpressed comparing CRCs bearing a specific BGA to CRCs not bearing it and as “UpT” or “DownT” if upregulated or downregulated in cancer compared to normal tissue. BGA-associated effects were evaluated by changes in the “Chromosomal Distribution Index” (CDI) of different transcript classes. Data show that UpT are more sensitive than DownT to BCNA-associated gene dosage effects. “Over-UpT” genes are upregulated in cancer and further overexpressed by gene dosage, defining the so called “positive caricature transcriptomic effect”. When Over-UpT genes are ranked according to overexpression, top positions are occupied by genes implicated at the functional and therapeutic level in CRC. We show that cancer-upregulated transcripts are sensitive markers of BCNA-induced effects and suggest that analysis of positive caricature transcriptomic effects can provide clues toward the identification of BCNA-associated cancer driver genes.

Titolo:	Positive Caricature Transcriptomic Effects Associated with Broad Genomic Aberrations in Colorectal Cancer
Autori interni:	CONDORELLI, Daniele Filippo (Corresponding) SPAMPINATO, GIORGIA VALENTI, GIOVANNA MUSSO, NICOLO' CASTORINA, Sergio BARRESI, VINCENZA (Corresponding)
Data di pubblicazione:	2018
Rivista:	SCIENTIFIC REPORTS
Handle:	http://hdl.handle.net/20.500.11769/361669
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/361669

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