We read with great interest the well performed study in the October issue, “Low-level laser therapy increases interleukin-1b in gingival crevicular fluid and enhances the rate of orthodontic tooth movement” (Varella AM, Revankar AV, Patil AK. Am J Orthod Dentofacial Orthop 2018;154:535-44.e5), on the effects of low-level laser therapy on interleukin (IL) 1b levels in gingival crevicular fluid and its correlation with orthodontic tooth movement. As stated in the article,1 orthodontic tooth movement is a highly complex process defined as an adaptive biologic response to interference in the physiologic equilibrium of the dentofacial structures by an externally applied force,2 from both biomechanical and biologic points of view. This stress, which accumulates over time in the periodontal apparatus, can result in a significant reduction in the speed of the tooth movement and in the relative orthodontic treatment length, a condition that sometimes determines the success of the treatment. Among the possible agents for dental movement, lowlevel laser therapy (LLLT) has been shown to be a valid method that sustains tooth movement by means of the photobiostimulation effect which would allow a greater speed of orthodontic movement.3 The tissue-stimulating effect induced by LLLT is also due to the biologic growth and metabolic changes of soft and hard oral tissues, which stimulates, in the long term, a better bone and tissue neoformation process, which also facilitates a greater shift in the shortest time.4 Moreover, the use of LLLT in the orthodontic field has been shown to be effective in tissue biostimulation, with stimulating effects in tissue repair and dental displacement, as well as inhibiting the release of pain mediators related to analgesia.5 Therefore, due to the importance of the topic analyzed in the study, we have some comments about some missing points of their detailed and well performed analysis. As reported by Varella et al,1 their treated patient presented increased levels of IL-1b in the experimental teeth treated with LLLT compared with the control canines, with a positive correlation between the IL-1b levels and the amounts of tooth movement across all time intervals. In this regard, did the authors also analyze the IL-10 levels and the IL-1b/IL-10 ratio? Previous investigators have suggested that a higher IL-1b/IL-10 ratio may be correlated with a

Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement

Isola, Gaetano
Writing – Review & Editing
;
Ferlito, Sebastiano
Data Curation
;
Rapisarda, Ernesto
Conceptualization
2019-01-01

Abstract

We read with great interest the well performed study in the October issue, “Low-level laser therapy increases interleukin-1b in gingival crevicular fluid and enhances the rate of orthodontic tooth movement” (Varella AM, Revankar AV, Patil AK. Am J Orthod Dentofacial Orthop 2018;154:535-44.e5), on the effects of low-level laser therapy on interleukin (IL) 1b levels in gingival crevicular fluid and its correlation with orthodontic tooth movement. As stated in the article,1 orthodontic tooth movement is a highly complex process defined as an adaptive biologic response to interference in the physiologic equilibrium of the dentofacial structures by an externally applied force,2 from both biomechanical and biologic points of view. This stress, which accumulates over time in the periodontal apparatus, can result in a significant reduction in the speed of the tooth movement and in the relative orthodontic treatment length, a condition that sometimes determines the success of the treatment. Among the possible agents for dental movement, lowlevel laser therapy (LLLT) has been shown to be a valid method that sustains tooth movement by means of the photobiostimulation effect which would allow a greater speed of orthodontic movement.3 The tissue-stimulating effect induced by LLLT is also due to the biologic growth and metabolic changes of soft and hard oral tissues, which stimulates, in the long term, a better bone and tissue neoformation process, which also facilitates a greater shift in the shortest time.4 Moreover, the use of LLLT in the orthodontic field has been shown to be effective in tissue biostimulation, with stimulating effects in tissue repair and dental displacement, as well as inhibiting the release of pain mediators related to analgesia.5 Therefore, due to the importance of the topic analyzed in the study, we have some comments about some missing points of their detailed and well performed analysis. As reported by Varella et al,1 their treated patient presented increased levels of IL-1b in the experimental teeth treated with LLLT compared with the control canines, with a positive correlation between the IL-1b levels and the amounts of tooth movement across all time intervals. In this regard, did the authors also analyze the IL-10 levels and the IL-1b/IL-10 ratio? Previous investigators have suggested that a higher IL-1b/IL-10 ratio may be correlated with a
2019
Orthodontics
File in questo prodotto:
File Dimensione Formato  
Isola et al AJODO 2019.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Dimensione 65.66 kB
Formato Adobe PDF
65.66 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/362628
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact