It is well known that ischemia and the reperfusion process are distinct nonimmunological events that negatively impact graft outcome and induce delayed graft function, which are associated with high rates of organ failure, retransplantation, and death. Cooling the organ slows metabolism but does not prevent its progressive dysfunction and destruction of cellular integrity. On the other hand, in the reperfusion phase, the reactive oxygen metabolites cause leukocyte accumulation and therefore increased microvascular permeability and cellular injury. This article is protected by copyright. All rights reserved.

Normothermic Machine Perfusion in Liver Transplantation: Avoiding Recooling Before Engrafting Is Feasible and Promising

Gruttadauria, Salvatore
2019-01-01

Abstract

It is well known that ischemia and the reperfusion process are distinct nonimmunological events that negatively impact graft outcome and induce delayed graft function, which are associated with high rates of organ failure, retransplantation, and death. Cooling the organ slows metabolism but does not prevent its progressive dysfunction and destruction of cellular integrity. On the other hand, in the reperfusion phase, the reactive oxygen metabolites cause leukocyte accumulation and therefore increased microvascular permeability and cellular injury. This article is protected by copyright. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/363330
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