Several studies indicate that the re-establishment of a physiological ecosystem by the re-colonization of vaginal mucosa with lactobacilli is an effective strategy for treating and preventing vaginal dysbiosis. We aimed to analyse the effects of a vaginal probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract and its ability to restore physiological conditions in women with symptomatic vaginitis. We conducted a uncontrolled clinical trial on 60 heathy and regularly menstruated women aged 18 to 45 with symptomatic bacterial vaginitis and a positive history for recurrences. All enrolled women were directed to apply a vaginal tablet containing a probiotic preparation of Lactobacillus acidophilus LA14, lactic acid and deodorized garlic extract according to the following schedule: 1 tablet/day for 14 consecutive nights. Overall a significant restoration (p<0.05) of the eubiosis condition was observed when data detected at baseline (T0) were compared with those detected 14 days after the start of treatment (T1) and 4 weeks after the end of treatment (T2). In only 9 cases (15%) a clinical and microbiological diagnosis of vaginitis was confirmed at T2. The relapse occurred in only 2 cases (3%). Vaginally administered probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract is safe and effective in treatment and prevention of symptomatic bacterial vaginitis.
|Titolo:||Efficacy of vaginal preparation containing lactobacillus acidophilus, lactic acid and deodorized garlic extract in treatment and prevention of symptomatic bacterial vaginitis: Result from a single-arm pilot study|
RAPISARDA, AGNESE MARIA CHIARA (Corresponding)
|Data di pubblicazione:||2018|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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