Several studies indicate that the re-establishment of a physiological ecosystem by the re-colonization of vaginal mucosa with lactobacilli is an effective strategy for treating and preventing vaginal dysbiosis. We aimed to analyse the effects of a vaginal probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract and its ability to restore physiological conditions in women with symptomatic vaginitis. We conducted a uncontrolled clinical trial on 60 heathy and regularly menstruated women aged 18 to 45 with symptomatic bacterial vaginitis and a positive history for recurrences. All enrolled women were directed to apply a vaginal tablet containing a probiotic preparation of Lactobacillus acidophilus LA14, lactic acid and deodorized garlic extract according to the following schedule: 1 tablet/day for 14 consecutive nights. Overall a significant restoration (p<0.05) of the eubiosis condition was observed when data detected at baseline (T0) were compared with those detected 14 days after the start of treatment (T1) and 4 weeks after the end of treatment (T2). In only 9 cases (15%) a clinical and microbiological diagnosis of vaginitis was confirmed at T2. The relapse occurred in only 2 cases (3%). Vaginally administered probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract is safe and effective in treatment and prevention of symptomatic bacterial vaginitis.

Efficacy of vaginal preparation containing lactobacillus acidophilus, lactic acid and deodorized garlic extract in treatment and prevention of symptomatic bacterial vaginitis: Result from a single-arm pilot study

Rapisarda, Agnese Maria Chiara
Primo
Membro del Collaboration Group
;
Caldaci, Lisa
Secondo
Membro del Collaboration Group
;
Valenti, Gaetano
Membro del Collaboration Group
;
Brescia, Roberta
Membro del Collaboration Group
;
Sapia, Fabrizio
Membro del Collaboration Group
;
Sarpietro, Giuseppe
Membro del Collaboration Group
;
BAMBILI, ELISA
Membro del Collaboration Group
;
Panella, Marco Marzio
Ultimo
2018-01-01

Abstract

Several studies indicate that the re-establishment of a physiological ecosystem by the re-colonization of vaginal mucosa with lactobacilli is an effective strategy for treating and preventing vaginal dysbiosis. We aimed to analyse the effects of a vaginal probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract and its ability to restore physiological conditions in women with symptomatic vaginitis. We conducted a uncontrolled clinical trial on 60 heathy and regularly menstruated women aged 18 to 45 with symptomatic bacterial vaginitis and a positive history for recurrences. All enrolled women were directed to apply a vaginal tablet containing a probiotic preparation of Lactobacillus acidophilus LA14, lactic acid and deodorized garlic extract according to the following schedule: 1 tablet/day for 14 consecutive nights. Overall a significant restoration (p<0.05) of the eubiosis condition was observed when data detected at baseline (T0) were compared with those detected 14 days after the start of treatment (T1) and 4 weeks after the end of treatment (T2). In only 9 cases (15%) a clinical and microbiological diagnosis of vaginitis was confirmed at T2. The relapse occurred in only 2 cases (3%). Vaginally administered probiotic preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract is safe and effective in treatment and prevention of symptomatic bacterial vaginitis.
2018
Lactobacillus; Probiotics; Vaginal dysbiosis; Vaginal microbiota; Vaginitis; Obstetrics and Gynecology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/364635
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