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EnglishOBJECTIVE: We explored the efficacy of intravenous therapy with propionyl L-carnitine in patients with both peripheral arterial disease (PAD) and chronic renal insufficiency requiring haemodialysis.METHODS: The trial was a randomised, double-blind, placebo-controlled trial. Sixty-four patients on haemodialysis (32 per treatment arm) with chronic renal insufficiency and PAD were assigned to receive either intravenous propionyl L-carnitine 600 mg or placebo 3 times weekly for 12 months. The main outcome measures were the ankle/brachial index (ABI), plasma malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) concentrations, and the plasma nitrite/nitrate ratio (NO(2)/NO(3)); these were measured at baseline and at 6 and 12 months.RESULTS: Significant increases in ABI were observed in the propionyl L-carnitine group, whereas in the placebo group the reverse trend was seen. In patients treated with propionyl L-carnitine, significant progressive decreases were seen in plasma MDA, 4-HNE and the NO(2)/NO(3) ratio from baseline. In the placebo-treated group, only weakly significant or no differences were seen.CONCLUSION: Intravenous administration of propionyl L-carnitine to haemodialysis patients with PAD improves both haemodynamic flow and the oxidative profile.
A RANDOMISED, CONTROLLED CLINICAL TRIAL EVALUATING CHANGES IN THERAPEUTIC EFFICACY AND OXIDATIVE PARAMETERS AFTER TREATMENT WITH PROPIONYL L -CARNITINE IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE REQUIRING HAEMODIALYSIS / S.S. SIGNORELLI; P. FATUZZO; RAPISARDA F; S. NERI; M. FERRANTE; G. M. OLIVERI CONTI; R. FALLICO; L. DI PINO; G. PENNISI; G. CELOTTA; A. MASSIMILIANO. - In: DRUGS & AGING. - ISSN 1170-229X. - 23(3)(2006), pp. 263-270.
| Titolo: | A RANDOMISED, CONTROLLED CLINICAL TRIAL EVALUATING CHANGES IN THERAPEUTIC EFFICACY AND OXIDATIVE PARAMETERS AFTER TREATMENT WITH PROPIONYL L -CARNITINE IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE REQUIRING HAEMODIALYSIS |
| Autori interni: | |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| Citazione: | A RANDOMISED, CONTROLLED CLINICAL TRIAL EVALUATING CHANGES IN THERAPEUTIC EFFICACY AND OXIDATIVE PARAMETERS AFTER TREATMENT WITH PROPIONYL L -CARNITINE IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE REQUIRING HAEMODIALYSIS / S.S. SIGNORELLI; P. FATUZZO; RAPISARDA F; S. NERI; M. FERRANTE; G. M. OLIVERI CONTI; R. FALLICO; L. DI PINO; G. PENNISI; G. CELOTTA; A. MASSIMILIANO. - In: DRUGS & AGING. - ISSN 1170-229X. - 23(3)(2006), pp. 263-270. |
| Handle: | http://hdl.handle.net/20.500.11769/36631 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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