The pathogenesis of gastroduodenal lesions after portacaval shunt has not yet been determined. The aim of our study was to evaluate ultrastructural changes of the gastric mucosa after portacaval shunt in the rat. One hundred and twenty rats were used. Electron and light microscopy were performed, one and six months after portacaval shunt. Rats manifested alterations of the gastric mucosa; erosion of the epithelial cells, areas of missing mucosal lining, increase in the number of parietal cells and hyperplasia of the enterochromaffin cells. As these gastric lesions were found in all specimens, we believe that portacaval shunt could be proposed as a model to evaluate H2 receptor antagonists in the treatment of gastroduodenal lesions.
Ultrastructural changes of the gastric mucosa after portocaval shunt in the rat.A new model to study H2 receptor antagonist?
DI CATALDO, Antonio;LI DESTRI, Giovanni;CASTORINA, Sergio;PULEO, Stefano
1990-01-01
Abstract
The pathogenesis of gastroduodenal lesions after portacaval shunt has not yet been determined. The aim of our study was to evaluate ultrastructural changes of the gastric mucosa after portacaval shunt in the rat. One hundred and twenty rats were used. Electron and light microscopy were performed, one and six months after portacaval shunt. Rats manifested alterations of the gastric mucosa; erosion of the epithelial cells, areas of missing mucosal lining, increase in the number of parietal cells and hyperplasia of the enterochromaffin cells. As these gastric lesions were found in all specimens, we believe that portacaval shunt could be proposed as a model to evaluate H2 receptor antagonists in the treatment of gastroduodenal lesions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
