The transient photochemistry of tolmetin (TM), 5-(p-toluoyl)-1-methyl-2-pyrrolyacetic acid, a drug belonging to the nonsteroidal anti-inflammatory class, has been studied in aqueous solution by using nanosecond falser flash photolysis techniques. The photoreactivity of TM is characterized by an adiabatic pathway involving a triplet carbanion as the key intermediate in the photodecarboxylation. A short-lived triplet is proposed as the precursor of this transient species. A minor channel for laser photodecomposition involving photoionization has also been identified. This latter photoprocess occurs predominantly through a biphotonic mechanism. RI Sortino, Salvatore/E-4684-2011
Laser flash photolysis of tolmetin: A photoadiabatic decarboxylation with a triplet carbanion as the key intermediate in the photodecomposition
SORTINO, Salvatore;
1999-01-01
Abstract
The transient photochemistry of tolmetin (TM), 5-(p-toluoyl)-1-methyl-2-pyrrolyacetic acid, a drug belonging to the nonsteroidal anti-inflammatory class, has been studied in aqueous solution by using nanosecond falser flash photolysis techniques. The photoreactivity of TM is characterized by an adiabatic pathway involving a triplet carbanion as the key intermediate in the photodecarboxylation. A short-lived triplet is proposed as the precursor of this transient species. A minor channel for laser photodecomposition involving photoionization has also been identified. This latter photoprocess occurs predominantly through a biphotonic mechanism. RI Sortino, Salvatore/E-4684-2011I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
