The photochemistry of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) has been studied in the beta-cyclodextrin cavity by stationary and time-resolved (picosecond and nanosecond) spectroscopic techniques. Conformational calculations of the inclusion complex were performed. Induced circular dichroism was measured and theoretically interpreted Photodecarboxylation was found to occur with lower quantum yield than in aqueous medium. An additional photoreaction was evidenced. A mechanism in which the lowest triplet state of the Ketoprofen-beta-cyclodextrin inclusion complex undergoes both intramolecular electron transfer and hydrogen abstraction is proposed. Adducts of reduced ketoprofen with beta-cyclodextrin are the likely photoproducts of the additional reaction channel. RI Monti, Sandra/B-9272-2009; Sortino, Salvatore/E-4684-2011

Supramolecular photochemistry of 2-(3-benzoylphenyl)propionic acid (Ketoprofen). A study in the beta-cyclodextrin cavity

SORTINO, Salvatore;DE GUIDI, Guido;
1998

Abstract

The photochemistry of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) has been studied in the beta-cyclodextrin cavity by stationary and time-resolved (picosecond and nanosecond) spectroscopic techniques. Conformational calculations of the inclusion complex were performed. Induced circular dichroism was measured and theoretically interpreted Photodecarboxylation was found to occur with lower quantum yield than in aqueous medium. An additional photoreaction was evidenced. A mechanism in which the lowest triplet state of the Ketoprofen-beta-cyclodextrin inclusion complex undergoes both intramolecular electron transfer and hydrogen abstraction is proposed. Adducts of reduced ketoprofen with beta-cyclodextrin are the likely photoproducts of the additional reaction channel. RI Monti, Sandra/B-9272-2009; Sortino, Salvatore/E-4684-2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/36780
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