Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
|Titolo:||SUMOylation in glioblastoma: A novel therapeutic target|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||1.1 Articolo in rivista|