Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.

SUMOylation in glioblastoma: A novel therapeutic target

Vicario N.;
2019-01-01

Abstract

Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
2019
Glioblastoma (gbm); Post-translational modifications (ptms); Sumo1-3; Sumoylation; Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Glioblastoma; Humans; Molecular Targeted Therapy; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Sumoylation
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/368682
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