Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

Soto Parra H.;
1998

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
Hodgkin's disease; Ifosfamide; Recurrent disease; Salvage therapy; Vinorelbine; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Hodgkin Disease; Humans; Ifosfamide; Male; Middle Aged; Neutropenia; Pilot Projects; Recurrence; Salvage Therapy; Treatment Outcome; Vinblastine; Vinorelbine
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/369942
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