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EnglishThe presence of extracellular amyloid-beta (A beta) plaques is one of the pathological hallmarks of Alzheimer's disease. Appropriately functionalized compounds can modulate amyloidogenesis. Here, we report a new class of cyclodextrin (CyD) derivatives rationally designed to improve the A beta recognition and to modulate its aggregation. In particular, a dimethylamino aromatic moiety was conjugated to beta CyD or gamma CyD to explore how different structural aspects of these derivatives could influence the recognition and the aggregation of A beta. The conjugation of the A beta recognition moiety to CyDs resulted in a significant suppression of the self-assembly propensity of A beta when the dimethylamino aromatic moiety was attached to the upper rim of beta CyD. The activity of the derivatives toward A beta confirms that the conjugation of CyDs with A beta recognition moieties may be considered a promising approach for designing new molecules that interfere with A beta aggregation.
| Titolo: | Synthesis and Evaluation of New Cyclodextrin Derivatives as Amyloid-β Aggregation Inhibitors |
| Autori interni: | |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11769/372163 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/20.500.11769/372163
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