Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on beta-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.
Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting
Giachino, Carmela;Vecchio, Graziella
2019-01-01
Abstract
Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on beta-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.File in questo prodotto:
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