Several lines of evidence suggest that a decline of serum testosterone levels occur in the aging male. This condition is called late-onset hypogonadism (LOH). Current guidelines suggest testosterone replacement therapy (TRT) when total testosterone (TT) is lower than 9.2 nmol/L. However, the clinical management of patients showing signs and symptoms suggestive for LOH but with TT in the lowest quartile of the normal range and/or having higher than the expected testosterone annual reduction velocity is not covered. This editorial aims to discuss this hot topic, suggesting a possible management.

Symptomatic late-onset hypogonadism but normal total testosterone: the importance of testosterone annual decrease velocity

Sandro La Vignera;Rosita A. Condorelli;Aldo E. Calogero;Rossella Cannarella;Laura M. Mongioì;Ylenia Duca;Laura Cimino;Filippo Giacone;
2019-01-01

Abstract

Several lines of evidence suggest that a decline of serum testosterone levels occur in the aging male. This condition is called late-onset hypogonadism (LOH). Current guidelines suggest testosterone replacement therapy (TRT) when total testosterone (TT) is lower than 9.2 nmol/L. However, the clinical management of patients showing signs and symptoms suggestive for LOH but with TT in the lowest quartile of the normal range and/or having higher than the expected testosterone annual reduction velocity is not covered. This editorial aims to discuss this hot topic, suggesting a possible management.
2019
Late-onset hypogonadism; testosterone annual reduction velocity; testosterone replacement therapy (TRT)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/373894
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