All cases of Cytomegalvirus-related disease in previously healthy immunocompetent subjects admitted to the University Hospital of Catania between 1990 and 2000 were reviewed. Eighty-one immunocompetent subjects were discharged with a diagnosis of acute cytomegalic disease. Nevertheless, only in 26 cases was the diagnosis confirmed by the determination of the specific immunoglobulin M, viremia or antigenemia. Fifteen subjects presented with a mononucleosis-like syndrome. Eleven subjects had a more severe form of the disease with organ involvement: 3 hepatitis, 3 interstitial pneumonia, 2 aseptic meningitis, 2 ulcerative colitis and 1 peripheral vasculitis. All patients recovered. Two out of 11 severe cases were treated with ganciclovir and 7 with steroids; the remainder received only supportive treatment. Large-scale surveys are required to assess the real impact of Cytomegalovirus disease in immunocompetent subjects and to elaborate guidelines for the management of severe cases.

Clinical features of cytomegalic disease in immunocompetent subjects: 1990-2000 survey

CACOPARDO B.;
2003

Abstract

All cases of Cytomegalvirus-related disease in previously healthy immunocompetent subjects admitted to the University Hospital of Catania between 1990 and 2000 were reviewed. Eighty-one immunocompetent subjects were discharged with a diagnosis of acute cytomegalic disease. Nevertheless, only in 26 cases was the diagnosis confirmed by the determination of the specific immunoglobulin M, viremia or antigenemia. Fifteen subjects presented with a mononucleosis-like syndrome. Eleven subjects had a more severe form of the disease with organ involvement: 3 hepatitis, 3 interstitial pneumonia, 2 aseptic meningitis, 2 ulcerative colitis and 1 peripheral vasculitis. All patients recovered. Two out of 11 severe cases were treated with ganciclovir and 7 with steroids; the remainder received only supportive treatment. Large-scale surveys are required to assess the real impact of Cytomegalovirus disease in immunocompetent subjects and to elaborate guidelines for the management of severe cases.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/38276
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