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English1. Neurobiol Dis. 2008 May;30(2):234-42.TGF-beta 1 protects against Abeta-neurotoxicity via thephosphatidylinositol-3-kinase pathway.Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F,Nicoletti F, Sortino MA, Copani A.Department of Pharmaceutical Sciences, University of Catania, 95125, Catania,Italy. carafil@hotmail.combeta-Amyloid (A beta) injection into the rat dorsal hippocampus had a smallneurotoxic effect that was amplified by i.c.v. injection of SB431542, a selectiveinhibitor of transforming growth factor-beta (TGF-beta) receptor. This suggested that TGF-beta acts as a factor limiting A beta toxicity. We examined theneuroprotective activity of TGF-beta1 in pure cultures of rat cortical neuronschallenged with A beta. Neuronal death triggered by A beta is known to proceedalong an aberrant re-activation of the cell cycle, and involves late beta-catenindegradation and tau hyperphosphorylation. TGF-beta1 was equally protective whenadded either in combination with, or 6 h after A beta. Co-added TGF-beta1prevented A beta-induced cell cycle reactivation, whereas lately added TGF-beta1 had no effect on the cell cycle, but rescued the late beta-catenin degradationand tau hyperphosphorylation. The phosphatidylinositol-3-kinase (PI-3-K)inhibitor, LY294402, abrogated all effects. Thus, TGF-beta1 blocks the wholecascade of events leading to A beta neurotoxicity by activating the PI-3-Kpathway.
TGF-ß1 protects against Aß-neurotoxicity via the phosphatidylinositol-3-kinase pathway / CARACI F; BATTAGLIA G; BUSCETI C; BIAGIONI F; MASTROIACOVO F; BOSCO P; DRAGO F; NICOLETTI F; SORTINO M.A; COPANI A.. - In: NEUROBIOLOGY OF DISEASE. - ISSN 0969-9961. - 30(2008), pp. 234-242.
| Titolo: | TGF-ß1 protects against Aß-neurotoxicity via the phosphatidylinositol-3-kinase pathway |
| Autori interni: | |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Citazione: | TGF-ß1 protects against Aß-neurotoxicity via the phosphatidylinositol-3-kinase pathway / CARACI F; BATTAGLIA G; BUSCETI C; BIAGIONI F; MASTROIACOVO F; BOSCO P; DRAGO F; NICOLETTI F; SORTINO M.A; COPANI A.. - In: NEUROBIOLOGY OF DISEASE. - ISSN 0969-9961. - 30(2008), pp. 234-242. |
| Handle: | http://hdl.handle.net/20.500.11769/3836 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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